ea0056p611 | Steroid metabolism + action | ECE2018
Kaikaew Kasiphak
, Steenbergen Jacobie
, Kroon Jan
, Meijer Onno C
, Grefhorst Aldo
, Visser Jenny A
Introduction: Glucocorticoids (GCs) are widely used anti-inflammatory medications that cause many metabolic side effects. Long-term treatment with GCs causes obesity and induces insulin resistance in many metabolic tissues, including adipose tissue and muscle. Factors secreted by adipose tissue, so-called adipokines, including leptin and adiponectin, also regulate the glucose-insulin axis. Obesity increases circulating leptin but decreases adiponectin levels. Despite several s...